解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Thanks to the growing interest in personalized medicine, joint modeling of longitudinal marker and time-to-event data has recently started to be used to derive dynamic individual risk predictions. Individual predictions are called dynamic because they are updated when information on the subject's health profile grows ...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/biom.12232
更新日期:2015-03-01 00:00:00
abstract::Pocock et al. (2012, European Heart Journal 33, 176-182) proposed a win ratio approach to analyzing composite endpoints comprised of outcomes with different clinical priorities. In this article, we establish a statistical framework for this approach. We derive the null hypothesis and propose a closed-form variance est...
journal_title:Biometrics
pub_type: 杂志文章,随机对照试验
doi:10.1111/biom.12225
更新日期:2015-03-01 00:00:00
abstract::Mixed latent Markov (MLM) models represent an important tool of analysis of longitudinal data when response variables are affected by time-fixed and time-varying unobserved heterogeneity, in which the latter is accounted for by a hidden Markov chain. In order to avoid bias when using a model of this type in the presen...
journal_title:Biometrics
pub_type: 杂志文章,随机对照试验
doi:10.1111/biom.12224
更新日期:2015-03-01 00:00:00
abstract::Receiver operating characteristic (ROC) analysis is widely used to evaluate the performance of diagnostic tests with continuous or ordinal responses. A popular study design for assessing the accuracy of diagnostic tests involves multiple readers interpreting multiple diagnostic test results, called the multi-reader, m...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/biom.12240
更新日期:2014-12-01 00:00:00
abstract::In the context of state-space modeling, conventional usage of the deviance information criterion (DIC) evaluates the ability of the model to predict an observation at time t given the underlying state at time t. Motivated by the failure of conventional DIC to clearly choose between competing multivariate nonlinear Bay...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/biom.12237
更新日期:2014-12-01 00:00:00
abstract::Many techniques of functional data analysis require choosing a measure of distance between functions, with the most common choice being L2 distance. In this article we show that using a weighted L2 distance, with a judiciously chosen weight function, can improve the performance of various statistical methods for funct...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/biom.12161
更新日期:2014-09-01 00:00:00
abstract::Interference occurs when the treatment of one person affects the outcome of another. For example, in infectious diseases, whether one individual is vaccinated may affect whether another individual becomes infected or develops disease. Quantifying such indirect (or spillover) effects of vaccination could have important...
journal_title:Biometrics
pub_type: 杂志文章,随机对照试验
doi:10.1111/biom.12184
更新日期:2014-09-01 00:00:00
abstract::We consider inference for the reaction rates in discretely observed networks such as those found in models for systems biology, population ecology, and epidemics. Most such networks are neither slow enough nor small enough for inference via the true state-dependent Markov jump process to be feasible. Typically, infere...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/biom.12152
更新日期:2014-06-01 00:00:00
abstract::Matched case-control designs are commonly used in epidemiologic studies for increased efficiency. These designs have recently been introduced to the setting of modern imaging and genomic studies, which are characterized by high-dimensional covariates. However, appropriate statistical analyses that adjust for the match...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/biom.12113
更新日期:2014-03-01 00:00:00
abstract::Epidemiological studies involving biomarkers are often hindered by prohibitively expensive laboratory tests. Strategically pooling specimens prior to performing these lab assays has been shown to effectively reduce cost with minimal information loss in a logistic regression setting. When the goal is to perform regress...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/biom.12134
更新日期:2014-03-01 00:00:00
abstract::A transformed Bernstein polynomial that is centered at standard parametric families, such as Weibull or log-logistic, is proposed for use in the accelerated hazards model. This class provides a convenient way towards creating a Bayesian nonparametric prior for smooth densities, blending the merits of parametric and no...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/biom.12104
更新日期:2014-03-01 00:00:00
abstract::We develop a Bayesian nonparametric mixture modeling framework for quantal bioassay settings. The approach is built upon modeling dose-dependent response distributions. We adopt a structured nonparametric prior mixture model, which induces a monotonicity restriction for the dose-response curve. Particular emphasis is ...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/biom.12120
更新日期:2014-03-01 00:00:00
abstract::Traditional studies of short-term air pollution health effects use time series data, while cohort studies generally focus on long-term effects. There is increasing interest in exploiting individual level cohort data to assess short-term health effects in order to understand the mechanisms and time scales of action. We...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/biom.12125
更新日期:2014-03-01 00:00:00
abstract::Estimation of treatment effects in randomized studies is often hampered by possible selection bias induced by conditioning on or adjusting for a variable measured post-randomization. One approach to obviate such selection bias is to consider inference about treatment effects within principal strata, that is, principal...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/biom.12103
更新日期:2013-12-01 00:00:00
abstract::For many long-lived animal species, individuals do not breed every year, and are often not accessible during non-breeding periods. Individuals exhibit site fidelity if they return to the same breeding colony or spawning ground when they breed. If capture and recapture is only possible at the breeding site, temporary e...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/biom.12094
更新日期:2013-12-01 00:00:00
abstract::Some covariate-adaptive randomization methods have been used in clinical trials for a long time, but little theoretical work has been done about testing hypotheses under covariate-adaptive randomization until Shao et al. (2010) who provided a theory with detailed discussion for responses under linear models. In this a...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/biom.12062
更新日期:2013-12-01 00:00:00
abstract::Because the number of patients waiting for organ transplants exceeds the number of organs available, a better understanding of how transplantation affects the distribution of residual lifetime is needed to improve organ allocation. However, there has been little work to assess the survival benefit of transplantation f...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/biom.12084
更新日期:2013-12-01 00:00:00
abstract::Logistic regression is a popular tool for risk analysis in medical and population health science. With continuous response data, it is common to create a dichotomous outcome for logistic regression analysis by specifying a threshold for positivity. Fitting a linear regression to the nondichotomized response variable a...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/biom.12007
更新日期:2013-06-01 00:00:00
abstract::Directed acyclic graphical (DAG) models are increasingly employed in the study of physical and biological systems to model direct influences between variables. Identifying the graph from data is a challenging endeavor, which can be more reasonably tackled if the variables are assumed to satisfy a given ordering; in th...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/biom.12018
更新日期:2013-06-01 00:00:00
abstract::In this article, we consider two-phase sampling in the situation in which all covariates are categorical. Two-phase designs are appealing from an efficiency perspective since they allow sampling to be concentrated in informative cells. A number of likelihood-based methods have been developed for the analysis of two-ph...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/biom.12019
更新日期:2013-06-01 00:00:00
abstract::Patients who were previously treated for prostate cancer with radiation therapy are monitored at regular intervals using a laboratory test called Prostate Specific Antigen (PSA). If the value of the PSA test starts to rise, this is an indication that the prostate cancer is more likely to recur, and the patient may wis...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2012.01823.x
更新日期:2013-03-01 00:00:00
abstract::We propose a nonparametric Bayesian approach to estimate the natural direct and indirect effects through a mediator in the setting of a continuous mediator and a binary response. Several conditional independence assumptions are introduced (with corresponding sensitivity parameters) to make these effects identifiable f...
journal_title:Biometrics
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1541-0420.2012.01781.x
更新日期:2012-12-01 00:00:00
abstract::In diagnostic medicine, estimating the diagnostic accuracy of a group of raters or medical tests relative to the gold standard is often the primary goal. When a gold standard is absent, latent class models where the unknown gold standard test is treated as a latent variable are often used. However, these models have b...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2012.01789.x
更新日期:2012-12-01 00:00:00
abstract::Exposure to high levels of air pollution during the pregnancy is associated with increased probability of preterm birth (PTB), a major cause of infant morbidity and mortality. New statistical methodology is required to specifically determine when a particular pollutant impacts the PTB outcome, to determine the role of...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2012.01774.x
更新日期:2012-12-01 00:00:00
abstract::Given a large number of t-statistics, we consider the problem of approximating the distribution of noncentrality parameters (NCPs) by a continuous density. This problem is closely related to the control of false discovery rates (FDR) in massive hypothesis testing applications, e.g., microarray gene expression analysis...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2012.01764.x
更新日期:2012-12-01 00:00:00
abstract::We explore the use of a posterior predictive loss criterion for model selection for incomplete longitudinal data. We begin by identifying a property that most model selection criteria for incomplete data should consider. We then show that a straightforward extension of the Gelfand and Ghosh (1998, Biometrika, 85, 1-11...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2012.01766.x
更新日期:2012-12-01 00:00:00
abstract::We estimate how the effect of antiretroviral treatment depends on the time from HIV-infection to initiation of treatment, using observational data. A major challenge in making inferences from such observational data arises from biases associated with the nonrandom assignment of treatment, for example bias induced by d...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2011.01738.x
更新日期:2012-09-01 00:00:00
abstract::In this article, we investigate clustering methods for multilevel functional data, which consist of repeated random functions observed for a large number of units (e.g., genes) at multiple subunits (e.g., bacteria types). To describe the within- and between variability induced by the hierarchical structure in the data...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2011.01714.x
更新日期:2012-09-01 00:00:00
abstract::This article develops a variety of influence measures for carrying out perturbation (or sensitivity) analysis to joint models of longitudinal and survival data (JMLS) in Bayesian analysis. A perturbation model is introduced to characterize individual and global perturbations to the three components of a Bayesian model...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2012.01745.x
更新日期:2012-09-01 00:00:00
abstract::In this article, we demonstrate a statistical method for fitting the parameters of a sophisticated network and epidemic model to disease data. The pattern of contacts between hosts is described by a class of dyadic independence exponential-family random graph models (ERGMs), whereas the transmission process that runs ...
journal_title:Biometrics
pub_type: 历史文章,杂志文章
doi:10.1111/j.1541-0420.2012.01748.x
更新日期:2012-09-01 00:00:00
abstract::Inference regarding the inclusion or exclusion of random effects in linear mixed models is challenging because the variance components are located on the boundary of their parameter space under the usual null hypothesis. As a result, the asymptotic null distribution of the Wald, score, and likelihood ratio tests will ...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2011.01675.x
更新日期:2012-06-01 00:00:00
abstract::There has been great interest in developing nonlinear structural equation models and associated statistical inference procedures, including estimation and model selection methods. In this paper a general semiparametric structural equation model (SSEM) is developed in which the structural equation is composed of nonpar...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2012.01751.x
更新日期:2012-06-01 00:00:00
abstract::Differential equations are extensively used for modeling dynamics of physical processes in many scientific fields such as engineering, physics, and biomedical sciences. Parameter estimation of differential equation models is a challenging problem because of high computational cost and high-dimensional parameter space....
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2012.01752.x
更新日期:2012-06-01 00:00:00
abstract::In multivariate matching, fine balance constrains the marginal distributions of a nominal variable in treated and matched control groups to be identical without constraining who is matched to whom. In this way, a fine balance constraint can balance a nominal variable with many levels while focusing efforts on other mo...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2011.01691.x
更新日期:2012-06-01 00:00:00
abstract::We propose optimal choice of the design parameters for random discontinuation designs (RDD) using a Bayesian decision-theoretic approach. We consider applications of RDDs to oncology phase II studies evaluating activity of cytostatic agents. The design consists of two stages. The preliminary open-label stage treats al...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2011.01623.x
更新日期:2012-03-01 00:00:00
abstract::In principle, G-estimation is an attractive approach for dealing with confounding by variables affected by treatment. It has rarely been applied for estimation of the effects of treatment on failure-time outcomes. Part of this is due to artificial censoring, an analytic device which considers some subjects who actuall...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2011.01656.x
更新日期:2012-03-01 00:00:00
abstract::We describe a Bayesian quantile regression model that uses a confirmatory factor structure for part of the design matrix. This model is appropriate when the covariates are indicators of scientifically determined latent factors, and it is these latent factors that analysts seek to include as predictors in the quantile ...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2011.01639.x
更新日期:2012-03-01 00:00:00
abstract::Many statistical tests have been proposed for case-control data to detect disease association with multiple single nucleotide polymorphisms (SNPs) in linkage disequilibrium. The main reason for the existence of so many tests is that each test aims to detect one or two aspects of many possible distributional difference...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2011.01649.x
更新日期:2012-03-01 00:00:00
abstract::We propose a new criterion for confounder selection when the underlying causal structure is unknown and only limited knowledge is available. We assume all covariates being considered are pretreatment variables and that for each covariate it is known (i) whether the covariate is a cause of treatment, and (ii) whether t...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2011.01619.x
更新日期:2011-12-01 00:00:00
abstract::In Western countries where food supply is satisfactory, consumers organize their diets around a large combination of foods. It is the purpose of this article to examine how recent nonnegative matrix factorization (NMF) techniques can be applied to food consumption data to understand these combinations. Such data are n...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2011.01588.x
更新日期:2011-12-01 00:00:00